The largest members of the Local Group can be seen with the unaided eye under a clear, dark sky. The easiest to see is the Andromeda galaxy. Binoculars will reveal its two satellite galaxies—M32 and M110.
The Triangulum galaxy can be seen with the unaided eye only under the darkest skies, but in general, binoculars are needed to detect this, the third largest member of the Local Group.
The most easily seen members of the Local Group are the two large fuzzy patches near the south celestial pole—the Large and Small Magellanic Clouds. These two galaxies occupy several degrees of sky and are quite easy to observe, especially the Large Magellanic Cloud.
M54—unlike all the other globular clusters in Messier's catalog—is not part of the Milky Way; it's part of the Sagittarius dwarf elliptical galaxy, our second nearest galactic neighbor. M54 is about 90,000 light-years away and easily visible with binoculars as a bright fuzzy star within the Teapot in the constellation Sagittarius.
And don't forget to look for the galaxy we call home, which from our location inside it we see as a band containing billions of faint stars stretching across the sky, a river of light our ancestors named the Milky Way.
Select a member of the Local Group to see if that object is visible in your sky tonight: